Louis Lewin, perhaps the best known researcher of
péyotl, published a book about psychoactive drugs in 1924. This was written in German, and bore the title
Phantastica: Die Betäubenden und Erregenden Genufsmittel. Für Arzte und Nichtärzte. There was a chapter on
péyotl, classified with other drugs as Phantastica, the word Lewin coined for entheogens. The English version of this important work, published in London in 1931, as expained in the introduction to this chapter, caught the attention of Aldous Huxley, and fired his interest in
pschopharmaka, eventually leading to his famous mescaline experience in May 1953, immortalized in his essay
The Doors of Perception (Huxley 1954). This was an important stimulus to use of entheogens in the sixties, as were the publications on self-experiments with mescaline by French writer Henri Michaux. Sometime before Huxley's famous initiation to entheogens, the American novelist William Burroughs ingested
péyotl. He reported on the effects, and mentioned that the drug was legal, in his first book,
Junk, originally published as
Junkie: Confessions of an Unredeemed Drug Addict under the pseudonym William Lee. Burroughs commented that, after ingesting four "buttons," "everything I saw looked like a peyote plant," and, other than that curious visual alteration, "I didn't feel any different from ordinary except high like on benny [
Benzedrine]. Burroughs' writing on drugs had considerable influence on the Beats, many of whom, like Allen Ginsberg, began to experiement with
péyotl, and there were reports in the sixties of "trips" by non-Indians. As a result, the existing legal mail-order market for
péyotl buttons began to expand.
In response to spreading use of entheogenic drugs, especially LSD, in the sixties, most countries followed the lead of the United States and illegalized these drugs, in effect making them available, with bureaucratic difficulties, to scientists only. Both
péyotl and mescaline were classified as controlled substances with "a high potential for abuse" and "no currently accepted medical use". Simple possession of
péyotl and mescaline became criminal offenses. Prior to this legislation,
péyotl and mescaline were rather freely available, at least in the United States. There is, however, no evidence that mescaline in pure form was ever widely used by the general public. Rather, most sixties users were introduced to entheogenic drugs by taking LSD. Being inexpensive to manufacture (on a
perdose basis), LSD continued to be available after federal and state legislation made it illegal. Mescaline, on the other hand, all but disappeared from the market. Today it is available to researchers as the hydrochloride, hemi-sulfate or sulfate salt, for $71.10
per gram (or $30-$40 for a decent does) from Sigma Chemical Co. (1993), which sells such research compounds labeled "not for drug use." Researchers in the United States must, however, be licensed by the Drug Enforcement Administration (DEA) in order to buy mescaline, and must have on file with the National Institute on Drug Abuse (NIDA) a research protocol demonstrating their "legitimate" need for the drug. Laboratories using mescaline and other controlled substances are subject to inspection by DEA agents, must have their licenses on display, and must have provisions for safeguarding the drugs, to avoid "diversion" (a curious bureaucratic
double entendre).
Mescaline sulfate, probably synthetic, is today available in limited amounts on the illicit market, selling for about $250 a gram. The entire supply however, seems to be taken up by the elite of the illicit drug trade, and this rare compound is not widely distributed. Note that at this price, an average 500 mg dose would cost at least $125!
Péyotl "buttons" are considerably more economical. In 1966, the going rate was $15 for 1000 buttons. Owing to the increasing demand and limited supply, this price had jumped to $80
per thousand buttons by 1983; although "green" (fresh)
péyotl could still be had for $15
per thousand buttons. By 1987, the price had again jumped to $100 for a thousand buttons, the current price. These prices refer to the legitimate trade between professional
peyoteros and the Native American Church. Even at the 1987 price, a five-button dose could be had wholesale for only 50¢—a true bargain!
Drugs alleged to be mescaline have been widely sold on the illicit market since the sixties. Analysis of street drug samples sold as "mescaline" almost invariably shows these to be LSD or PCP (phencyclidine or
Sernyl, a veterinary tranquilizer). Amphetamines have on occasion been detected in putative mescaline samples. The rare specimens found to contain mescaline have been crystals or white powder; capsules,
not tablets.
Summarizing analyses of 640 putative mescaline samples in four different American laboratories, Brown and Malone reported only 18 mescaline samples and 8
péyotl samples (1.2%). The remainder were as follows: 376 LSD (58.8%); 130 LSD plus PCP (20.3%); 27 PCP (4.2%); and 81 "other" (12.7%) including a few mixtures of LSD plus amphetamines; "STP" or DOM; a few amphetamine samples,
etc. The alleged "mescaline" tablets or capsules weighed from 10-150 mg each, insufficient to provoke a mescaline "trip" even were they 100% mescaline! In similar analyses made in Munich, Germany, only 1 of 14 putative mescaline samples (7.1%) was found to be genuine. Of 61 purported mescaline preparations analyzed by PharmChem Laboratories in Palo Alto, California in 1973, 52 or 85% contained LSD, while only 4 samples (6.6%) actually contained mescaline.
Virtually all American users of entheogenic drugs claim to have tried mescaline at some point in their careers. Clearly, the vast majority have simply tried LSD or PCP under an assumed name. There can be no doubt about this conclusion—mescaline has always been in short supply, and numerous studies on street drug samples support this view. Moreover, a 400-600 mg dose of pure mescaline sulfate will fill two or three large "00" capsules, and most users report having ingested only one capsule or tablet. Yet "sophisticated" users, when confronted with these facts, will usually claim that they have certainly tried the real thing, that they know the difference between LSD and mescaline, being
connaisseurs; that LSD has this or that attribute, whereas mescaline may be distinguished by various superior qualities.
To put it plainly, this is hogwash. Not only have the great majority of entheogen users never tried authentic mescaline but, I submit, under proper experimental conditions, few would be able to discern much diffference between mescaline and LSD. IN fact, the effects of these compounds are remarkably similar, and these drugs (as well as psilocybine and psilocine) show cross-tolerance, suggesting they produce their effects by similar neural mechanisms. There is some evidence they may all bind to the same receptor in brains of experimental animals.
Why then, all this fanfare about mescaline, the philosophers' "stone" of psychedelia? If street "mescaline" is only LSD, why do users invariably believe it to be different, superior, "cleaner," more desirable than LSD? I must digress a bit to arrive at a satisfactory answer.
In the late fifties, a new tranquilizer known as
Thalidomide was admitted for medical use in Germany and other countries. It became apparent that the drug was strongly teratogenic, that is, that it produced grave birth defects if taken at the wrong time by pregnant women. The tragic result was a generation of "
Thalidomide babies" with hideous and crippling deformities. The drug was immediately taken off the market, and regulations concerning the introduction of new drugs were tightened considerably in many countries.
At this time, under the trade name
Delysid, LSD was being distributed as an experimental drug by Sandoz Ltd. of Switzerland. Since the drug was thought to produce a "model psychosis," Sandoz felt it might ultimately be an effective psychotherapeutic agent, and indeed it showed considerable promise in early trials. When in 1967 a report in the
New England Journal of Medicine alleged that LSD caused chromosome damage, the scare was on. No matter that the report did not support this allegation, which in later controlled experiments proved to be false, or show that LSD is teratogenic (it is not). The media and governments seized this allegation as a means of attacking LSD use, which was spreading rapidly. The media mounted a vigorous scare campaign against LSD, which continues to this day.
LSD users in the sixties were principally in their late teens or early twenties, and many had vivid memories of the well-publicized
Thalidomide tragedy, which had been graphically and luridly chronicled by the press. Many people came to fear LSD as a result of the scare campaign. Popular interest in LSD had stimulated interest in other entheogenic drugs. One result was the reprinting of Huxley's and Kluver's hitherto obscure books on mescaline, and an increasing awareness that LSD was not the only entheogenic drug.
In 1968 Carlos Castaneda published
The Teachings of Don Juan: A Yaqui Way of Knowledge, which referred to
péyotl use, and must have stimulated interest in mescaline, since Castaneda imputed to Don Juan, supposedly a Mexican shaman, the belief that
Mescalito was the spirit of
péyotl. This is certainly spurious. As I have shown, European scientists in the last century confused
péyotl with
mescal, a word originally referring to a completely different plant, and mescaline as the active principle of
péyotl is decidedly a misnomer. Are we to believe that a Mexican shaman is party to this confusion?
Meanwhile, there was already a sizable black market LSD industry in place, and wily drug dealers seized on "mescaline" as a means to offset any declining sales of LSD brought on by the big scare. They labeled LSD as "mescaline" or "organic mescaline" and foisted the specious preparation on the unsuspecting public. The term "organic mescaline" is significant—
organic mescaline was preferred by the
connaisseur to ordinary or (we must presume)
synthetic mescaline! What is the meaning of the term "organic"? To the chemist
organic chemistry is the chemistry of carbon compounds, such diverse compounds as LSD, mescaline,
Thalidomide, strychnine, DDT, TNT (and literally millions of others, whether made by a plant or by a chemist) are alike
organic compounds. The meaning imputed to "organic mescaline" was that it was a natural compound, from a plant, in contrast to LSD, which was a creation of the chemist not found in nature (at least not yet). Thus, I submit, was born the great mescaline hoax. Some users of entheogens came to fear LSD because of a scare campaign by governments and the press. LSD was, after all, an artificial compound, and an unknown quantity. It had not existed prior to 1938 and little was known about the long-term consequences of its use. Mescaline, on the other hand, was extracted from a plant which had been used by human beings for millennia (though most "psychedelic" users did not know this), was a natrual compound—it was "organic" and therefore safe!
Thus was born a linguistic confusion which persists to this day. Debate still rages about the relative virtues of "natural"
versus "synthetic" vitamins, "processed"
versus "organic" foods. Whether synthesized by a chemist or by a plant, any given vitamin samples of identical chemical structure have identical biological effects. The same is true for drugs. Mescaline made by the
péyotl cactus is the same as mescaline made by a chemist. As a rule, however, synthetic natural products (whether drugs or vitamins)
are of superior purity to their natural counterparts as these normally are available commercially.
I have seemingly touched on a modern example of the primal fear of the gods. Drugs and vitamins made by human beings are thought to be unnatural and dangerous, whereas identical drugs and vitamins made by plants are god-given and safe. To presume to make things formerly made only by the gods is to commit the sin of Prometheus, to steal fire from the gods!
I have explained why LSD came to be misrepresented as mescaline, but why did LSD users consider it to be a superior high, if in fact street "mescaline" were simply LSD under an assumed name, the wolf in sheep's clothing? It is well known that user expectation or "set" is an important determining factor in the quality of entheogenic drug experiences. Users wanted to believe that "mescaline" was different, so they could join the
cognoscenti who alone were party to superior knowledge of a drug safer and more desirable than the suspect LSD. Drug sellers readily reinforced this tendency in the gullible users. An elaborate folklore grew to surround mescaline, in spite of the fact that hardly anyone had ever tried it! "Mescaline" was usually priced higer than LSD, which was at once conducive to expanded profit for the seller, and a heightened feeling on the part of the user that (s)he was a member of the elite. It is now widely known among users that "mescaline" sold on the street is and has ever been almost invariably misrepresented. Nonetheless, nearly everyone believes that (s)he has actually tried the real thing, that (s)he is a part of a yet smaller elite, and that it is everyone else who has been duped!
In the 1980s, as part of a widespread "nature tourism" or "ecotourism" movement (I first heard the term
ecotourism, in Spanish, from the lips of a Quijos Quichua
ayahuasquera in Amazonian Ecuador!) there arose the phenomenon of Mexican "
péyotl tours" to the land of the Huichol. Advertised in magazines like
Magical Blend Magazine and
Shaman's Drum: A Journal of Experientational Shamanism, such tours invited prospective clients to visit Huichol "places of power" and to study "advanced techniques of shamanic healing" with Huichol shamans. In the Fall of 1986 issue of
Shaman's Drum (which featured articles on the Huicholes), there were no fewer than three advertisements for "
péyotl tours." To the credit of the magazine's publishers, there was also a letter to the editor by S. Valadez, wife of a Huichol artist whose work was depicted in the issue, decrying "Guided tour spiritualty: Cosmic way or cosmic rip-off?" ... Valadez warned:
Westerners who participate in peyote pilgrimages with Huichols... are endangering the Huichols who escort them. The soldiers patrolling the peyote desert are not impressed by Americans who claim they come for enlightenment. The Mexicans think the outsiders come for dope, and accuse the Huichols of dealing drugs to the "gringo Hippies."
I have seen a similar phenomenon surrounding entheogenic mushroom use in Oaxaca in the seventies (even María Sabina was sent to prison for "dealing drugs to the
gringo hippies"), and I share Valadez's concerns, which also include cultural disruption and spreading of diseases by highly-mobile outsiders to isolated communites of unimmunized Indians. Finally, as outlined below, excessive and destructive harvesting is endangering the small, slow-growing species
Lophophora williamsii, which has a restricted range. I personally think outsiders should stay home and take LSD or grown their own
San Pedro.